Gentamicin sulphate nephrotoxicity seems to be attributed to the generation of reactive oxygen species. The aim of this study was to investigate the protective effect of quercetin on cisplatininduced nephrotoxicity in rats. The plant extract of rhazya stricta has been noted to dosedependently increase the superoxide dismutase activity and the reducedform of glutathione and subsequently decrease lipid peroxides in the renal cortex of gentamicin administered rats. Protective effects of piperine on lead acetate inducednephrotoxicity in rats. Material and methodsmale sprague dawley rats n 42 were. In the present study, we examined effect of oleuropein on the paraoxonase 1 pon1 activity, lipid peroxidation, lipid profile, atherogenic indexes, and relationship of pon1 activity by highdensity lipoproteincholesterol hdlc and atherogenic indices in gentamicin gminduced nephrotoxicity in rats. Adult male albinos wistar rats were randomly divided into four groups. Review on nephroprotective activity study by different plant extract paoulomi chatterjee 1. Pdf cadmium induced hepatotoxicity in rats and the. The cisplatin single dose administration to rats induced nephrotoxicity associated with a significant increase in blood urea nitrogen bun and. The present study was aimed to investigate the influence of thymoquinone tq, a compound isolated from nigella sativa plant with predominant antioxidant property on a rat model of gminduced nephrotoxicity. Pdf due to high relative blood flow the kidney is prone to druginduced damage. Acute rapamycin nephrotoxicity in native kidneys of patients with chronic glomerulopathies.
Drugs and toxins may cause renal injury based on several pathophysiological mechanisms. Comparative nephrotoxicity of aminoglycoside antibiotics in rats. Drug induced impairment of renal function george sunny pazhayattil, anushree c shirali section of nephrology, yale university school of medicine, new haven, ct, usa abstract. Free radicals play an important role in the renal injury induced by gentamicin kadkhodaee et al. Nephrotoxic effects of aminoglycosides on the developing.
And although druginduced nephrotoxicity may occur in dogs of any. Calcium dobesilate for prevention of gentamicininduced. Cilostazol attenuates gentamicininduced nephrotoxicity in. Efficacy of curcumin on lead induced nephrotoxicity in female. Forty eight male rats were divided randomly into six groups. Nephrotoxicity is an important and preventable cause of nephrotoxin induced acute kidney injury aki as well as chronic kidney disease ckd. Abstract the present study was carried out to determine the severe hepatotoxicity and nephrotoxicity of gasoline on liver, kidney, hematological and oxidative stress parameters in wistar male albino rats. Jaegook shin, dong hyun kim, characterization of urinary metabolites as biomarkers of colistininduced nephrotoxicity in rats by a liquid chromatographymass spectrometrybased metabolomics. The aim of this study was to evaluate the inhibitory effect of ole on gentamicininduced nephrotoxicity in rats. Identification of metabolomic biomarkers for druginduced acute kidney injury in rats. Fom decreased nedaplatininduced nephrotoxicity, as shown by reduced blood urea nitrogen bun, serum creatinine levels, and urinary excretion of nacetyl. Flavocoxid attenuates gentamicin induced nephrotoxicity in rats. Pdf gentamicin induced nephrotoxicity in albino mice.
Molecular mechanism of drug induced nephrotoxicity 6,509 views. Captopril enhances aminoglycoside nephrotoxicity in. Rates of creatinine clearance ccr, pathological scores, and concentrations of drug pgg in the kidneys of rats 15 days after injection with various regimens at low, middle, or high doses. Therefore, successful prevention requires knowledge of pathogenic mechanisms of renal injury, patientrelated risk factors, drugrelated risk factors, and preemptive measures, coupled with early identification and intervention. Extracts at the doses 200 and 400 mgkgday for 10 consecutive days, by intraperitoneal route i. Morin, a bioflavonoid with antioxidant properties, is a constituent of many herbs and fruits that are used as herbal medicines. Nephroprotective effect of herbal extract eurycoma longifolia on. International journal of therapeutic applications, volume 27, 2015, 1622 16 abrogation of cisplatininduced nephrotoxicity in rats by lycopene through ameliorating oxidative stress, inflammation and apoptosis elsayed m. Effect of dimethyl sulfoxide on gentamicin induced nephrotoxicity in rats. Druginduced impairment of renal function george sunny pazhayattil, anushree c shirali section of nephrology, yale university school of medicine, new haven, ct, usa abstract. Rats were divided into 6 groups randomly, each group including 8 animals. Environmental issues aminoglycosides antioxidants antioxidants nutrients cinnamon health aspects laboratory rats materia medica, vegetable plant extracts rats as laboratory animals toxicity research urea. Although aminoglycoside induced nephrotoxicity has been the subject of multiple studies, the short and longterm effect of aminoglycosides administration on the developing kidney of the fetus or premature newborn has not yet been determined. Nephrotoxicity induced by gentamicin has been found to be a complex phenomenon characterized by an.
Selected parameters of clinical pathology were measured and the kidney were evaluated by histopathology. Protective role of sodium selenite on mercuric chloride. Protective effect of rutin supplementation against cisplatininduced. Olive leaf extract ole has been demonstrated to have antioxidant and antiinflammatory effects. Attenuation of gentamicininduced nephrotoxicity in rats by fleroxacin article pdf available in antimicrobial agents and chemotherapy 416.
They were maintained under standard housing conditions with free. Oranges contain secondary metabolites such as flavonoids. Oleuropein is a natural antioxidant and scavenging free radicals. The present study aimed to identify metabolomic biomarkers that could provide early and sensitive indication of nephrotoxicity in rats. While most of these are clinically insignificant, some drugs. Inhibitory effect of olive leaf extract on gentamicininduced. The effect of fosfomycin on nedaplatininduced nephrotoxicity.
Drugs can cause inflammatory changes in the glomerulus, renal. Affymetrix genechip microarrays were used for gene expression analysis of the kidneys. In the study of gentamicin induced nephrotoxicity on rats, the dose of tested extract at 200600 mgkgday. Previously we studied the hydrogen peroxide scavenging activity of eryngium caucasicum. Animal models of acute renal failure polish academy of. The present study evaluates the nephroprotective effects of ursolic acid in a murine model of gentamicin induced renal damage. As explained, oxidative stress and inflammation are two factors contributing to gentamicininduced nephrotoxicity and regarding the antioxidant and antiinflammatory properties of crocin, the present study was designed to evaluate the protective effects of crocin against gentamicininduced renal disturbances in. Gentamicin, at doses of 50 or 100 mgkg body wt administered daily to healthy male mf1 mice by i. At this time the released nag is about sixfold more than the control. Pharmaceutical agents provide diagnostic and therapeutic utility that are central to patient care.
Oxidative stress plays a key role in leadinduced nephrotoxicity. Gentamicin gm is a widely used antibacterial antibiotic however its optimal clinical benefit is limited by its serious nephrotoxicity and ototoxicity. In the current study, the effects of the administration of aqueousethanolic extract of n. This work examines the influence of age on some nephrotoxic signs of gentamicin in normal and diabetic rats aged 1 and 24 months. The aim of this study was to evaluate the inhibitory effect of ole on gentamicin induced nephrotoxicity in rats. Druginduced kidney diseases np singh, a ganguli, a prakash abstract druginduced kidney disease constitutes an important cause of acute renal failure and chronic kidney disease in present day clinical practice. This biochemical measurements and histopathology analysis investigated a possible protective effect of 1,2diazole with regards to cisplatin induced nephrotoxicity in experimental animals. Nephroprotective effect of ursolic acid in a murine model. Zeynab mohamadi yarijani, houshang najafi, and seyed hamid madani. The plant extract of rhazya stricta has been noted to dosedependently increase the superoxide dismutase activity and the reducedform of glutathione and subsequently decrease lipid peroxides in the renal cortex of gentamicinadministered rats. The aim of the present study was to evaluate the protective effect of crocin against gentamicininduced nephrotoxicity in rats. The effect of fleroxacin on gentamicin induced nephrotoxicity was evaluated with female spraguedawley rats.
Severe hepatotoxicity and nephrotoxicity of gasoline. Druginduced nephrotoxicity remains a major problem as use of. Identification of genes involved in gentamicin induced. Druginduced nephrotoxicity refers to kidney damage induced by medication administered for the purpose of diagnosing or treating another medical disorder. Animals were injected during 4 or 10 days with saline nacl. The existence of genetic factors was suggested due to differences in the susceptibility to nephrotoxicity of rats, rabbits and other animals 3. Cox inhibition and gentamicin nephrotoxicity brazilian journal of medical and biological research 2004 37. Efficacy of curcumin on lead induced nephrotoxicity in. Research article nephroprotective effect of vitamin e and. The starting point for nephrotoxicity is the binding of the pharmacological agent to the proximal tubule. The effects of sex hormones on gm induced nephrotoxicity in gonadectomized rats were investigated. Influence of iron, deferoxamine and ascorbic acid on gentamicin induced nephrotoxicity in rats.
The first group of animals was potassium repleted, the second group was potassium depleted, and the third group was potassium depleted, but received the converting enzyme. Full text druginduced impairment of renal function ijnrd. In recent years gentamicin nephrotoxicity is significantly reduced by shifting to once. Inhibitory effects of cinnamon extract on gentamicininduced nephrotoxicity in mail adult wistar rats. The aim of the present study is to clarify the possible corrective role of curcumin on the nephrotoxicity induced by lead acetate. Cengizgentamicininduced nephrotoxicity in rats ameliorated and healing effects of resveratrol. Hence with this background we decided to explore the nephroprotective role of ursolic acid in a murine model which entails the use of a commonly available, economical, and most mechanistically studied model, that is, gentamicin induced nephrotoxicity in normal wistar albino rats.
Melamine was recently identified as a risk factor for renal calculi following the milk powder contamination in china. Protective effect of apocynin against gentamicininduced. It appears that osmoticallyinduced diuresis alone is insufficient to prevent or significantly reduce gentamicin nephrotoxicity in rats. Forty wistar rats were randomly divided into five groups of eight rats. Nephrotoxicity was induced by intraperitoneal injection of gentamicin 100 mgkg for 8 days. Osbeck against kidney histology of white wistar rats induced by gentamicin. Nephroprotective effect of punica granatum in gentamicin.
International journal of therapeutic applications issn. Renal functions of two rat groups were compared, one eating rat chow containing 2. Calcium dobesilate is an antioxidant drug and this study is aimed to investigate the effects of calcium dobesilate on gentamicininduced nephrotoxicity. A number of crude herbal extracts have been reported to ameliorate gentamicin induced nephrotoxicity. Attenuation of gentamicininduced nephrotoxicity in rats. This is in contrast to other forms of diuretic therapy, such as furosemide, which have been shown to effectively reduce renal accumulation and resultant renal toxicity of aminoglycoside administration. Osmotic diuresis with isosorbide did not significantly reduce the dosedependent extent of. We evaluated renal function and other adverse health effects using a rat model administered melamine and cyanuric aid, considering age and sex.
Protective effects of piperine on lead acetate inducednephrotoxicity. Original article, report by advances in environmental biology. Jul 27, 2015 drug induced nephrotoxicity can lead to acute kidney injury aki or chronic kidney disease in patients and is a major problem for clinicians 2,3. Cilostazol attenuates gentamicininduced nephrotoxicity in rats. Inhibitory effects of cinnamon extract on gentamicin. This study is designed to evaluate the protective effect of the hydroalcoholic extract of pistachio on gentamicininduced nephrotoxicity in rats. The protective effect of nigella sativa against cisplatin.
Gentamicininduced nephrotoxicity is a welldocumented event involving some functional and cellular mechanisms such as glomerular lesions that interfere with glomerular hemodynamics, and altered tubular transport, with the injury ranging from solely functional. This biochemical measurements and histopathology analysis investigated a possible protective effect of 1,2diazole with regards to cisplatininduced nephrotoxicity in. As explained, oxidative stress and inflammation are two factors contributing to gentamicin induced nephrotoxicity and regarding the antioxidant and antiinflammatory properties of crocin, the present study was designed to evaluate the protective effects of crocin against gentamicin induced renal disturbances in rats. Inhibitory effect of olive leaf extract on gentamicin. Effect of morin against gentamicininduced nephrotoxicity. Wistar albino rats of either sex, weighing 150200 g were divided into 5 groups. Thymoquinone supplementation protects against gentamicin. However, gentamicin administration is limited because of nephrotoxicity.
The origanum vulgare were grounded to fine powder, and extracted sequentially with chloroform. Amelioration of cisplatininduced nephrotoxicity in rats by curcumin and. Oxidative stress plays a key role in lead induced nephrotoxicity. It is a poisonous effect of some substances, both toxic chemicals and medications, on renal function. All animals were injected daily with gentamicin 100 mgkg s. Effect of morin against gentamicininduced nephrotoxicity in. Cadmiuminduced hepatotoxicity in rats and the protective effect of naringenin.
The effect of aepf 100mgkg given orally either with gentamicin or after 8 days of gentamicin administration was assessed by biochemical and histopathological changes of kidneys. Nephrotoxins are substances displaying nephrotoxicity. Longterm followup of nephrotoxicity in rats administered. Pdf in traditional medicine, different parts of elephantopus scaber linn are highly valued for the treatment of. A number of crude herbal extracts have been reported to ameliorate gentamicininduced nephrotoxicity. Pdf effect of withania somnifera on gentamicin induced. Recently, it has been shown that eryngium caucasicum can act as a free radical scavenger liao et al. There are various forms, and some drugs may affect renal function in more than one way. Inhibition by lithium and rubidium of gentamicininduced. Molecular mechanism of drug induced nephrotoxicity 1. Effect of superoxide dismutase treatment on gentamicin nephrotoxicity in rats. Amelioration of cisplatininduced nephrotoxicity in rats by. However, the longterm natural history of melamine exposure and its renal effects remain unknown.
Effect of morin against gentamicininduced nephrotoxicity in young male rats hala a. Recommendations issued for preventing druginduced nephrotoxicity. Severe hepatotoxicity and nephrotoxicity of gasoline petrol. Gentamicin 80 mg 1 kg 1 day for 6 days, intramuscularly produced the typical pattern of nephrotoxicity. Nephrotoxic effects of aminoglycosides on the developing kidney samira samieezafarghandy1. Nephrotoxicity is a common side effect observed during both nonclinical and clinical drug development investigations. Effect of cyclooxygenase inhibitors on gentamicininduced nephrotoxicity in rats. Preliminary toxicity study to determine the volume of gasoline that could cause toxicity was carried out using 56 healthy male albino rats. Protective effect of zingiber officinale on gentamicin. Effect of cyclooxygenase inhibitors on gentamicininduced. This work was conducted to evaluate the possible renoprotective effect of eryngium caucasicum against gentamicininduced renotoxicity. Prediction of druginduced nephrotoxicity and injury.
Amelioration of cisplatininduced nephrotoxicity in rats. Gentamicin gm induced nephrotoxicity may be sex hormones related. Nephroprotective effect of ursolic acid in a murine model of. Drug induced nephrotoxicity tends to be more common among certain patients and in specific clinical situations. The pathogenic mechanisms involved in glycerolinduced renal failure include ischemic injury, tubular nephrotoxicity caused by myoglobin, and the renal actions of cytokines re. Article information, pdf download for protective effect of apocynin against gentamicininduced. Identification of metabolomic biomarkers for druginduced. The effect of saireito, an oriental traditional medicine, against gentamicin nephrotoxicity was examined in gentamicin nephrotoxicity rat models. We studied gentamicin induced nephrotoxicity by determining the nag release in perfused rat kidney. Effect of saireito on gentamicin nephrotoxicity in rats.
Acrylamide induced acute nephrotoxicity in rats keivan jmahidi department of pathology, faculty of veterinary science, islamic azad university, garmsar branch, garmsar, iran abstract acrylamide acr has been shown to cause neurotoxic effects in humans and neurotoxic, genotoxic, reproductive, and carcinogenic effects in laboratory animals. Apo ameliorated the nephrotoxic effect and oxidative damage caused by gnt by improving tissue. To determine whether this enhanced toxicity was mediated by renin secretion, we evaluated the effect of a converting enzyme inhibitor in. We sought to unravel medicinal therapeutic function of w. Acute rapamycin nephrotoxicity in native kidneys of. Calcium dobesilate for prevention of gentamicin induced nephrotoxicity in rats mostafa jafarey,1 saeed changizi ashtiyani,2 houshang najafi3 introduction. Pdf protective effect of crocin on gentamicininduced. Protective effect of quercetin against gentamicininduced.
Different classes of drugs, by virtue of immunological mechanisms or direct toxicity initiate certain stereotyped renal responses. The spectrum of injury may vary from subtle to severe. Calcium dobesilate is an antioxidant drug and this study is aimed to investigate the effects of calcium dobesilate on gentamicin induced nephrotoxicity. Thirty mature female albino rats 190 225 g were randomly divided into five equal groups, first and second. Druginduced nephrotoxicity tends to be more common among certain patients and in specific clinical situations. Mar 31, 2015 molecular mechanism of drug induced nephrotoxicity 1. The origanum vulgare were grounded to fine powder, and extracted sequentially with chloroform, methanol and water. Riceberry bran extract prevents renal dysfunction and. Druginduced nephrotoxicity can lead to acute kidney injury aki or chronic kidney disease in patients and is a major problem for clinicians 2,3. Protective effect of crocin on gentamicininduced nephrotoxicity in rats. Gentamicin 30, 60, 120, 160 mgkg was administered s.
Inhibitory effects of cinnamon extract on gentamicininduced. The study was designed to investigate the possible protective role of sodium selenite in mercuric chloride induced renal stress, by using biochemical approaches. The effect of isosorbide diuresis on gentamicin excretion and tissue accumulation as well as gentamicin induced histopathologic changes in renal tissue were examined in rats. Captopril enhances aminoglycoside nephrotoxicity in potassium. The effect of coadministration of fosfomycin fom on nedaplatininduced nephrotoxicity in rats was investigated for 6 days. Clinical pharmacology for the nephrologist khaled eldahshan, md lecturer of nephrology, mansoura. Effect of morin against gentamicin induced nephrotoxicity in young male rats hala a.
In the current study a dose of 80 mgkg gentamicin was given daily to male rats for one week. Purposethis study investigated the protective effects of riceberry bran extract rbbe on renal function, and the function and expression of renal organic anion transporter 3 oat3 in gentamicin induced nephrotoxicity in rats and explored the mechanisms for its protective effects. However, all agents also carry adverse drug effect profiles. Biochemical effects of oleuropein in gentamicininduced. Nephrotoxic effects of aminoglycosides on the developing kidney. Calcium dobesilate for prevention of gentamicininduced nephrotoxicity in rats mostafa jafarey,1 saeed changizi ashtiyani,2 houshang najafi3 introduction. Captopril enhances aminoglycoside nephrotoxicity in potassiumdepleted rats.